Boronic acid, (4-ethylphenyl)- → HCID 23445382, compound

HRID 234320

Reaction equation

HRID 234320 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)[CH3:2].Br[C:13]1[S:17][C:16]([S:18]([N:21]2[CH:25]=[CH:24][CH:23]=[CH:22]2)(=[O:20])=[O:19])=[CH:15][CH:14]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:13]2[S:17][C:16]([S:18]([N:21]3[CH:25]=[CH:24][CH:23]=[CH:22]3)(=[O:19])=[O:20])=[CH:15][CH:14]=2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

Product 1

HCID 23445382HCID 23445382, compoundYield 81%

Procedure

N-[5-(4-ethylphenyl)thiophene-2-sulfonyl]pyrrole was prepared, in the same manner as described in Example 32C, from 4-ethylphenylboronic acid and N-(5-bromothiophenesulfonyl)pyrrole. Purification by column chromatography using 10% ethyl acetate/hexanes gave the pure sulfonamide as a tan solid in 81% yield.

Workup

  1. customPurification by column chromatography

Sources & evidence

ORD record
ord-3cfad4bb7beb4ac99de8b03712869ff0
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Linked notes

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