HCID 10909824, compound → 4-Isopropylthiazole-5-carbaldehyde
Reaction equation
[OH:1][CH2:2][C:3]1[S:7][CH:6]=[N:5][C:4]=1[CH:8]([CH3:10])[CH3:9]>C(Cl)(Cl)Cl.O=[Mn]=O>[CH:8]([C:4]1[N:5]=[CH:6][S:7][C:3]=1[CH:2]=[O:1])([CH3:10])[CH3:9]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 4.65 g (30 mmol) of crude 5-(hydroxymethyl)-4-isopropyl-thiazole in 200 mL of chloroform (CHCl3) was treated with 45 g of MnO2 and stirred at room temperature for 2.5 hours. The suspension was filtered, and the filtrate was concentrated. The residue was chromatographed on silica gel, eluting with 3:1 hexane:EtOAc, to give the title compound.
Workup
- filtrationThe suspension was filtered
- concentrationthe filtrate was concentrated
- customThe residue was chromatographed on silica gel
- washeluting with 3:1 hexane
Sources & evidence
- ORD record
- ord-06b404f5eb48426282f938d4be47ae15
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06852711B2
Reaction notes
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