4,4-Diphenylsemicarbazide → HCID 57100418, compound
Reaction equation
[CH3:1][O:2][C:3](=[O:18])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH2:8][CH2:9][CH:10]([CH:16]=O)[CH2:11]2.[C:19]1([N:25]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:26](=[O:29])[NH:27][NH2:28])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)C>[C:19]1([N:25]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:26](=[O:29])[NH:27][N:28]=[CH:16][CH:10]2[CH2:9][CH2:8][C:7]3[C:12](=[CH:13][CH:14]=[CH:15][C:6]=3[O:5][CH2:4][C:3]([O:2][CH3:1])=[O:18])[CH2:11]2)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of methyl(2-formyl-1,2,3,4-tetrahydronaphthalen-5-yl)oxyacetate (248 mg), prepared by the same procedure as reference example 1, m ethanol (10 ml) was added 4,4-diphenylsemicarbazide (0.27 g) under an atmosphere of argon. After stirred for 1 h at room temperature, the mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (methanol:methylene chloride=3:100) to give the title compound (444 mg) having the following physical data.