Cinchomeronic acid → 1H,3H-furo(3,4-c)pyridine-1,3-dione

HRID 234804

Reaction equation

HRID 234804 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[C:3]([C:10]([OH:12])=[O:11])[CH:2]=1>C(OC(=O)C)(=O)C>[N:1]1[CH:6]=[CH:5][C:4]2[C:7]([O:12][C:10](=[O:11])[C:3]=2[CH:2]=1)=[O:9]

Participants

3

Reactant 1

HCID 10273Cinchomeronic acid

Product 1

HCID 2783981H,3H-furo(3,4-c)pyridine-1,3-dioneYield 75.5%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A mixture of pyridine 3,4-dicarboxylic acid (15.0 g) and acetic anhydride (30 mL) is refluxed for two hours. The excess acetic anhydride is removed by distillation and the anhydride is collected and purified by sublimation (123° C. at 3 mm Hg) to yield pyridine 3,4-dicarboxylic acid anhydride as a white solid (10.1 g).

Workup

  1. temperatureis refluxed for two hours
  2. customThe excess acetic anhydride is removed by distillation
  3. customthe anhydride is collected
  4. custompurified by sublimation (123° C. at 3 mm Hg)

Sources & evidence

ORD record
ord-4dc1f62024d04909a387aae886214db3
Source dataset
uspto-grants-1997_01
Patent number
US05596097

Linked notes

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