2,4-Dichlorophenylacetonitrile → 2,4-Diamino-5-(2,4-dichlorophenyl)-6-trifluoromethylpyrimidine

HRID 234928

Reaction equation

HRID 234928 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12](Cl)[C:11]=2[Cl:17])=[C:5]([C:18]([F:21])([F:20])[F:19])[N:4]=1.[Cl:22]C1C=C(Cl)C=CC=1CC#N>>[NH2:2][C:3]1[N:8]=[C:7]([NH2:9])[C:6]([C:10]2[CH:15]=[CH:14][C:13]([Cl:22])=[CH:12][C:11]=2[Cl:17])=[C:5]([C:18]([F:21])([F:20])[F:19])[N:4]=1

Participants

3

Reactant 2

HCID 805662,4-DichlorophenylacetonitrileHCID 197050922,4-Diamino-5-(2,3-dichlorophenyl)-6-trifluoromethylpyrimidine hydrochloride

Product 1

HCID 116454832,4-Diamino-5-(2,4-dichlorophenyl)-6-trifluoromethylpyrimidine

Procedure

This compound was prepared in a manner analogous to the compound of Example 14 from 2,4-dichlorophenylacetonitrile (Aldrich): mp. 220.5°-221° C.

Sources & evidence

ORD record
ord-dd0ac7353642415682016cbdbd6efb2c
Source dataset
uspto-grants-1997_01
Patent number
US05597827

Linked notes

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