Sulfuric Acid → 2,4,5-Trifluorobenzamide

HRID 2351027

Reaction equation

HRID 2351027 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]#[N:5].S(=O)(=O)(O)[OH:13]>>[F:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:13]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 5938132,4,5-Trifluorobenzonitrile

Product 1

HCID 27769582,4,5-Trifluorobenzamide

Procedure

In 20 ml of 80% sulfuric acid was dissolved 5.8 g of 2,4,5-trifluorobenzonitrile and the mixture was heated under reflux for 30 minutes. After cooling, the reaction mixture was poured into ice-water and extracted with ethyl acetate. The extract was dried over sodium sulfate and the solvent was removed to yield 5.32 g of 2,4,5-trifluorobenzamide.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. extractionextracted with ethyl acetate
  5. dry with materialThe extract was dried over sodium sulfate
  6. customthe solvent was removed

Sources & evidence

ORD record
ord-02bb96cf642d4a6db1a242a2bebdc1e3
Source dataset
uspto-grants-1989_10
Patent number
US04871852

Linked notes

Loading…