Diethyl Sulfate → HCID 19856557, compound
Reaction equation
[Br:1][C:2]1[C:3](=[O:9])[NH:4][CH:5]=[C:6]([Br:8])[N:7]=1.[OH-].[Na+].C(=O)([O-])[O-].[Na+].[Na+].S(OCC)(O[CH2:22][CH3:23])(=O)=O>O>[CH2:22]([N:4]1[CH:5]=[C:6]([Br:8])[N:7]=[C:2]([Br:1])[C:3]1=[O:9])[CH3:23]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
6.2 g of 3,5-dibromo-pyrazin-2-one are suspended in a mixture of 38 ml of water, 11.1 ml of 2 N sodium hydroxide solution and 0.5 g of sodium carbonate. 4.3 g of diethyl sulfate are then added dropwise at 20°-25° C. and the mixture is subsequently stirred at the same temperature for 15 hours. The product is filtered off at 0° C., washed with ice-water and dried to give 4.6 g of 1-ethyl-3,5-dibromo-pyrazin-2-one.
Workup
- filtrationThe product is filtered off at 0° C.
- washwashed with ice-water
- customdried
Sources & evidence
- ORD record
- ord-e738456320634a1da128b631dc0f6271
- Source dataset
- uspto-grants-1989_10
- Patent number
- US04871853
Reaction notes
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