HCID 10814285, compound → HCID 11798102, compound
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH:12]([C:20]2[CH:25]=[CH:24][C:23]([CH2:26][CH2:27][CH2:28][C:29]([O:31]C)=[O:30])=[CH:22][CH:21]=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1>CO.[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH:12]([C:20]2[CH:21]=[CH:22][C:23]([CH2:26][CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[CH:24][CH:25]=2)[CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:9])=[O:10])=[CH:6][CH:7]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a suspension of 2.00 g of methyl 4-[4-[1-(4-chlorophenylsulfonylamino)-2-phenylethyl]phenyl]butyrate in 17 ml of methanol, 7.7 ml of 2N aqueous sodium hydroxide was added and stirring was continued at room temperature for 2 hours. The solvent was removed under reduced pressure. The residue was added with water, acidified with dilute hydrochloric acid, and then extracted with methylene chloride. After the methylene chloride layer was washed with water and dried, the solvent was removed under reduced pressure to yield 1.87 g of colorless crystals. Recrystallization from a mixture of isopropyl ether and ethyl acetate gave colorless needles, mp 152°~153° C.