N-Iodosuccinimide → 6-Chloro-3-iodoimidazo[1,2-b]pyridazine
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[N:7]=1.[I:11]N1C(=O)CCC1=O>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[N:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
14 g of 6-chloroimidazo[1,2-b]pyridazine (Example 1.0) were suspended in 364 ml of acetonitrile, and 20.51 g of N-iodosuccinimide were added. The mixture was stirred at RT for 19 hours. A further 4.31 g of N-iodosuccinimide were added, and the mixture was stirred for 24 hours. The reaction was cooled and the precipitated solid was filtered off with suction, washed with acetonitrile and dried. 17.67 g of the desired product are obtained.
Workup
- stirringthe mixture was stirred for 24 hours
- temperatureThe reaction was cooled
- filtrationthe precipitated solid was filtered off with suction
- washwashed with acetonitrile
- customdried
Sources & evidence
- ORD record
- ord-64e5ad2189f343bab1c797771545ad9a
- Source dataset
- uspto-grants-2010_07
- Patent number
- US07750000B2
Reaction notes
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