Ethanolamine → HCID 57418690, compound

Reaction equation

Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([I:11])=[CH:9][N:10]=2)[N:7]=1.[CH2:12]([CH2:14][NH2:15])[OH:13]>>[I:11][C:8]1[N:6]2[N:7]=[C:2]([NH:15][CH2:14][CH2:12][OH:13])[CH:3]=[CH:4][C:5]2=[N:10][CH:9]=1

Participants

Reactant 2

HCID 700Ethanolamine

HCID 532498976-Chloro-3-iodoimidazo[1,2-b]pyridazine

Product 1

HCID 57418690HCID 57418690, compoundYield 36.8%

Procedure

562 mg (2.0 mmol) of 6-chloro-3-iodoimidazo[1,2-b]pyridazine and 2.35 ml (39.2 mmol) of ethanolamine were stirred at 90° C. for 16 h. After cooling, the mixture was concentrated. The resulting residue was purified by chromatography (DCM/EtOH 9:1). 224 mg of the product were obtained.

Workup

temperatureAfter cooling
concentrationthe mixture was concentrated
customThe resulting residue was purified by chromatography (DCM/EtOH 9:1)

Sources & evidence

ORD record: ord-ffdaf7540f144583955b8582021ceb08
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750000B2

Reaction notes

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