Trifluoromethanesulfonyl chloride → N-(4-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-2-methyl-phenyl)-trifluoromethanesulfonamide

HRID 2354259

Reaction equation

HRID 2354259 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:13]2[CH:26]=[CH:25][C:16]([O:17][CH2:18][C:19](=[O:24])[C:20]([CH3:23])([CH3:22])[CH3:21])=[C:15]([CH3:27])[CH:14]=2)([CH2:11][CH3:12])[CH2:9][CH3:10])=[CH:4][C:3]=1[CH3:28].[F:29][C:30]([F:36])([F:35])[S:31](Cl)(=[O:33])=[O:32]>>[CH3:21][C:20]([CH3:22])([CH3:23])[C:19](=[O:24])[CH2:18][O:17][C:16]1[CH:25]=[CH:26][C:13]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:1][S:31]([C:30]([F:36])([F:35])[F:29])(=[O:33])=[O:32])=[C:3]([CH3:28])[CH:4]=2)([CH2:11][CH3:12])[CH2:9][CH3:10])=[CH:14][C:15]=1[CH3:27]

Participants

3

Reactant 2

HCID 79000Trifluoromethanesulfonyl chlorideHCID 684529431-{4-[1-(4-Amino-3-methyl-phenyl)-1-ethyl-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one

Product 1

HCID 11432273N-(4-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-2-methyl-phenyl)-trifluoromethanesulfonamide

Procedure

The title compound is prepared from 1-{4-[1-(4-amino-3-methyl-phenyl)-1-ethyl-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one and trifluoromethane sulfonyl chloride using a procedure analogoues to Example 17 (45%).

Sources & evidence

ORD record
ord-6b3d58594e7a4ab29e9c8c64e860481b
Source dataset
uspto-grants-2010_07
Patent number
US07750184B2

Linked notes

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