HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aminopyridazine → 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid PYRIDAZIN-3-YLAMIDE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aminopyridazine | HCID 230373 | — |
| Reactant | 6-{4-[2-(Trifluoromethyl)benzoyl]piperazin-1-yl}pyridazine-3-carbonyl chloride | HCID 86597230 | — |
| Product | 6-[4-(2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]PYRIDAZINE-3-CARBOXYLIC Acid PYRIDAZIN-3-YLAMIDE | HCID 16036441 | — |
Reaction Steps
Following the procedure of Example 28, making variations only as required to use pyridazin-3-ylamine in place of 2-aminopyridine to react with 6-[4-(2-trifluoromethylbenzoyl)-piperazin-1-yl]pyridazine-3-carbonyl chloride, the title compound was obtained as a white powder (17.3% yield). 1H NMR (300 MHz, CDCl3) δ 10.81, 9.05, 8.70, 8.13, 7.87-7.57, 7.39, 6.95, 4.16-3.80, 3.40. 13C NMR (300 MHz, CDCl3) δ 167.7, 162.3, 160.1, 148.6, 144.1, 132.4, 129.6, 128.1, 127.2, 126.9, 118.3, 112.1, 43.4, 44.6, 44.3, 41.3. MS (ES+) m/z 458.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07754711B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-4b583b06c09a484bb1b83d977612587f |
| Source note | uspto-grants-2010_07 |