HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 23564Generated: October 26, 2026
Water → 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine
https://huagongshe.com/reaction/23564
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Chloronicotinamide | HCID 80456 | — |
| Product | 4-tert-Butoxycarbonylamino-1-(5-aminocarbonyl-2-pyridyl)piperidine | HCID 11484042 | — |
Reaction Steps
A mixture of 3 g (0.015 mol) of the product of preparation 1, 1.5 g (0.015 mol) of triethylamine and 2.34 g (0.015 mol) of 6-chloronicotinamide in 60 ml of dimethylformamide is heated at 80° C. for 18 hours. After cooling, water is added and the product is filtered off. 2.8 g of the title compound are thus obtained. m.p. 255° C. dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06852736B2 |
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| Source dataset | uspto-grants-2005_02 |
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| ORD ID | ord-cea0b8f2a83640e79fadf2be389be974 |
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| Source note | uspto-grants-2005_02 |
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