Thionyl Chloride → Ethyl 6-(chloromethyl)pyridine-2-carboxylate--hydrogen chloride (1/1)

HRID 2356608

Reaction equation

HRID 2356608 reaction equation
O[CH2:2][C:3]1[N:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=1.S(Cl)([Cl:16])=O>ClCCl>[ClH:16].[Cl:16][CH2:2][C:3]1[N:8]=[C:7]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 109211412-Pyridinecarboxylic acid, 6-(hydroxymethyl)-, ethyl ester

Product 1

HCID 68457584Ethyl 6-(chloromethyl)pyridine-2-carboxylate--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

As for Reaction 1, using 45.14 g of ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate and 33 g thionyl chloride in 500 ml dichloromethane. Yield 59.9 g

Workup

  1. customAs for Reaction 1

Sources & evidence

ORD record
ord-183871bb9e68456ba638c22d39f17ad6
Source dataset
uspto-grants-2010_07
Patent number
US07759369B2

Linked notes

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