Boron tribromide → HCID 178524540, compound
Reaction equation
C[O:2][C:3](=[O:17])[C:4]1[C:9]([Cl:10])=[CH:8][C:7]([C:11]2[NH:15][N:14]=[N:13][N:12]=2)=[CH:6][C:5]=1[Cl:16].B(Br)(Br)Br>ClCCl>[Cl:16][C:5]1[CH:6]=[C:7]([C:11]2[NH:15][N:14]=[N:13][N:12]=2)[CH:8]=[C:9]([Cl:10])[C:4]=1[C:3]([OH:17])=[O:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The mixture of 110 mg of 2,6-dichloro-4-tetrazolylbenzoic acid methylester, 0.5 ml of dichloromethane solution containing 1M BBr3 and 5 ml of dichloromethane was stirred overnight. The obtained substance was treated by an ordinary method using dichloromethane as an extractant and purified by reverse phase HPLC to obtain the title compound.
Workup
- additionThe obtained substance was treated by an ordinary method
- custompurified by reverse phase HPLC
Sources & evidence
- ORD record
- ord-7f6e290710c34046a5d620053fc92c10
- Source dataset
- uspto-grants-2010_07
- Patent number
- US07759388B2
Reaction notes
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