7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine-4-carbaldehyde → 4-(1-Hydroxypropyl)-7-methoxy-2-trifluoromethyl-pyrazolo[1,5-a]pyridine

Reaction equation

[F:1][C:2]([F:17])([F:16])[C:3]1[CH:15]=[C:6]2[C:7]([CH:13]=[O:14])=[CH:8][CH:9]=[C:10]([O:11][CH3:12])[N:5]2[N:4]=1.[CH2:18]([Mg]Br)[CH3:19]>>[OH:14][CH:13]([C:7]1[C:6]2[N:5]([N:4]=[C:3]([C:2]([F:1])([F:16])[F:17])[CH:15]=2)[C:10]([O:11][CH3:12])=[CH:9][CH:8]=1)[CH2:18][CH3:19]

Participants

Reactant 2

HCID 593893517-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine-4-carbaldehyde

HCID 178418443HCID 178418443, compound

Product 1

HCID 593893854-(1-Hydroxypropyl)-7-methoxy-2-trifluoromethyl-pyrazolo[1,5-a]pyridine

Procedure

The compound of Example 115 was reacted with ethyl magnesium bromide as in Example 134 to afford the title compound as a pale yellow oil.

Sources & evidence

ORD record: ord-9db7c104fc4d4d16b282a1630c9892fb
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07763617B2

Reaction notes

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