Potassium Hydroxide → 5-(Furan-3-yl)-1,3-oxazole-4-carboxylic acid
Reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10][CH:9]=[N:8][C:7]=2[C:11]([O:13]C)=[O:12])=[CH:2]1.[OH-].[K+]>CO>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[O:10][CH:9]=[N:8][C:7]=2[C:11]([OH:13])=[O:12])=[CH:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3 g of methyl 5-(3-furyl)oxazole-4-carboxylate and 2.6 g of 85% potassium hydroxide are dissolved in 100 ml of methanol, and the solution is stirred at room temperature overnight. Then, the reaction mixture is evaporated under reduced pressure to remove solvent, and the residue is acidified with dil. hydrochloric acid. The precipitated crystals are collected by filtration, washed with cold water and then dried. 2.6 g of 5-(3-furyl)oxazole-4-carboxylic acid are thereby obtained. Yield: 93.7%
Workup
- customThen, the reaction mixture is evaporated under reduced pressure
- customto remove solvent
- filtrationThe precipitated crystals are collected by filtration
- washwashed with cold water
- customdried
Sources & evidence
- ORD record
- ord-47f38b7fbd97494f9e212cac11356d8f
- Source dataset
- uspto-grants-1987_02
- Patent number
- US04642313
Reaction notes
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