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Carbon Disulfide → 4-[(4-CHLOROPHENYL)METHYL]-2,3,6,7-TETRAHYDRO-2-THIOXO-1H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE MONOHYDRATE

HRID 236016
Notes
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Reaction equation

HRID 236016 reaction equation
[NH2:1][C:2]1[N:3]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C:4]2[N:5]([CH2:11][CH2:12][N:13]=2)[C:6](=[O:10])[C:7]=1[N:8]=[O:9].[C:22](=S)=[S:23]>[Pd].CO>[OH2:9].[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([CH2:14][N:3]2[C:2]3[NH:1][C:22](=[S:23])[NH:8][C:7]=3[C:6](=[O:10])[N:5]3[CH2:11][CH2:12][N:13]=[C:4]23)=[CH:16][CH:17]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 6348Carbon DisulfideHCID 178508072HCID 178508072, compound

Product 1

HCID 202177034-[(4-CHLOROPHENYL)METHYL]-2,3,6,7-TETRAHYDRO-2-THIOXO-1H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE MONOHYDRATE

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 5% palladium on carbon (1 g.) and 2.0 g. (0.0066 mole) of the product of Procedure 1 in MeOH (50 ml.) was hydrogenated until H2 uptake ceased. The catalyst was removed and carbon disulfide (0.5 g. 0.0066 mole) was added. The solution was refluxed for 4 hrs. and stirred at room temperature for 16 hrs. The mixture was concentrated in vacuo and the residue suspended in H2O (50 ml.), and refluxed for 6 hrs., cooled, and 1.55 g. of solid collected by filtration. The solid was dissolved in dil. NaOH, treated with activated carbon, and reprecipitated with HOAc to give 1.18 g. of product, m.p. 232°-235°.

Workup

  1. customThe catalyst was removed
  2. temperatureThe solution was refluxed for 4 hrs
  3. concentrationThe mixture was concentrated in vacuo
  4. temperaturerefluxed for 6 hrs
  5. temperature, cooled
  6. filtrationof solid collected by filtration
  7. dissolutionThe solid was dissolved in dil. NaOH
  8. additiontreated with activated carbon
  9. customreprecipitated with HOAc
  10. customto give 1.18 g

Sources & evidence

ORD record
ord-1c1f5c63965b48c58438fa451b3cdd73
Source dataset
uspto-grants-1987_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04642345

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes