3-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 66997805, compound

HRID 2360448

Reaction equation

HRID 2360448 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[CH2:11]([O:13][C:14]1[C:15]([F:23])=[C:16](B(O)O)[CH:17]=[CH:18][CH:19]=1)[CH3:12]>>[Cl:10][C:4]1[CH:3]=[C:2]([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH2:11][CH3:12])[C:15]=2[F:23])[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 162177593-Ethoxy-2-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 204346204-Bromo-2-chloro-6-fluoroaniline

Product 1

HCID 66997805HCID 66997805, compoundYield 43.2%

Procedure

The title compound (65 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (120 mg, 0.53 mmol) and 3-ethoxy-2-fluorophenylboronic acid (120 mg, 0.69 mmol) as a colourless liquid.

Sources & evidence

ORD record
ord-cc3d2de445f94b82bf046c813a399eab
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Linked notes

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