Acetone Cyanohydrin → 1-Benzyl-5-ethyl-2,2,5-trimethyl-piperazine

Reaction equation

[CH2:1]([N:8]1[CH2:17][C:16]([CH3:19])([CH3:18])[NH:15][CH2:14][C:9]21[CH2:13]CC[CH2:10]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20]C(N)(CC)CN.CC(C)(O)C#N>>[CH2:1]([N:8]1[CH2:17][C:16]([CH2:18][CH3:20])([CH3:19])[NH:15][CH2:14][C:9]1([CH3:10])[CH3:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 6406Acetone Cyanohydrin

HCID 226668532-Methylbutane-1,2-diamine

HCID 64842474HCID 64842474, compound

Product 1

HCID 648483321-Benzyl-5-ethyl-2,2,5-trimethyl-piperazine

Procedure

1-Benzyl-5-ethyl-2,2,5-trimethyl-piperazine was synthesized in analogy to 6-benzyl-8,8-dimethyl-6,9-diaza-spiro[4.5]decane starting from 2-methylbutane 1,2-diamine and acetone cyanohydrin.

Sources & evidence

ORD record: ord-e089367ac70e425ba25b7eb35699c2f8
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08686150B2

Reaction notes

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