Phosgene → N-[2-(Ethylamino)ethyl]-3-(phenylsulfonyl)-1-piperidinecarboxamide

HRID 236116

Reaction equation

C1(S(C2CCCNC2)(=O)=O)C=CC=CC=1.C(Cl)(Cl)=O.[C:20]1([S:26]([CH:29]2[CH2:34][CH2:33][CH2:32][N:31]([C:35](Cl)=[O:36])[CH2:30]2)(=[O:28])=[O:27])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH2:38]([NH:40][CH2:41][CH2:42][NH2:43])[CH3:39]>>[CH2:38]([NH:40][CH2:41][CH2:42][NH:43][C:35]([N:31]1[CH2:32][CH2:33][CH2:34][CH:29]([S:26]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=[O:28])=[O:27])[CH2:30]1)=[O:36])[CH3:39]

Participants

Reactant 4

HCID 6371Phosgene

HCID 66071N-Ethylethylenediamine

HCID 136079833-(Phenylsulfonyl)piperidine

HCID 202179433-(Phenylsulfonyl)piperidine-1-carbonylchloride

Product 1

HCID 20218051N-[2-(Ethylamino)ethyl]-3-(phenylsulfonyl)-1-piperidinecarboxamide

Procedure

The title compound is prepared by reacting 3-(phenylsulfonyl)piperidine with phosgene and reacting the resulting 3-(phenylsulfonyl)piperidine-1-carbonylchloride with N-ethylethylenediamine.

Sources & evidence

ORD record: ord-930bf7dbff764dd6bf5a9eedfd148a32
Source dataset: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04642348

Linked notes

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