4-Chloro-2-methylpyrimidine → HCID 59525761, compound

Reaction equation

[Br:1]C1N=C(CBr)C=CN=1.[Cl:10][C:11]1[CH:16]=[CH:15][N:14]=[C:13]([CH3:17])[N:12]=1>>[Br:1][CH2:17][C:13]1[N:12]=[C:11]([Cl:10])[CH:16]=[CH:15][N:14]=1

Participants

Reactant 2

HCID 4244474-Chloro-2-methylpyrimidine

HCID 86673424HCID 86673424, compound

Product 1

HCID 59525761HCID 59525761, compound

Procedure

Prepared according to the same procedure as 2-bromo-4-(bromomethyl)pyrimidine, starting with 4-chloro-2-methylpyrimidine. 1H NMR (500 MHz, DMSO-d6) δ 8.83 (d, J=5.5 Hz, 1H), 7.69 (d, J=5.5 Hz, 1H), 4.68 (s, 2H), Mass spec.: 208.9 (MH)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-c3994d5c65744155b93806f05441be1d
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08691821B2

Reaction notes

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