HCID 86673423, compound → HCID 86673427, compound

Reaction equation

FC1C=CC(F)=CC=1C[P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8].Br[CH2:19][C:20]1[CH:25]=[C:24]([Cl:26])[N:23]=[CH:22][N:21]=1>>[CH2:7]([O:6][P:5]([CH2:19][C:20]1[CH:25]=[C:24]([Cl:26])[N:23]=[CH:22][N:21]=1)(=[O:12])[O:9][CH2:10][CH3:11])[CH3:8]

Participants

Reactant 2

HCID 86673423HCID 86673423, compound

HCID 86673425HCID 86673425, compound

Product 1

HCID 86673427HCID 86673427, compound

Procedure

Prepared according to the same procedure as diethyl 2,5-difluorobenzylphosphonate, starting with 4-(bromomethyl)-6-chloropyrimidine. 1H NMR (500 MHz, DMSO-d6) δ 9.00 (s, 1H), 7.68 (dd, J=2.3, 1.1 Hz, 1H), 4.21-3.88 (m, 4H), 3.74-3.45 (m, 2H), 1.20 (t, J=7.0 Hz, 6H), Mass spec.: 265.1 (MH)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-23693eeb618949c8a6bb5feeb8f65dbd
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08691821B2

Reaction notes

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