Acetic Acid → 3-cyclopropyl-3,7-dihydro-8-methyl-1H-purine-2,6-dione
Reaction equation
[CH:1]1([N:4]2[C:9]([NH2:10])=[C:8]([NH2:11])[C:7](=[O:12])[NH:6][C:5]2=[O:13])[CH2:3][CH2:2]1.[C:14](O)(=O)[CH3:15]>>[CH:1]1([N:4]2[C:9]3[N:10]=[C:14]([CH3:15])[NH:11][C:8]=3[C:7](=[O:12])[NH:6][C:5]2=[O:13])[CH2:3][CH2:2]1Participants
3
Procedure
A solution of 6.4 g of 1-cyclopropyl-5,6-diamino-2,4-(1H,3H)-pyrimidinedione (IV) in 20 ml of acetic acid was refluxed for 2 hours. The solution was evaporated. The received oil was refluxed in 40 ml of 2N NaOH and 10 ml of 5N NaOH for 1 hour and then neutralized with 5N HCl. The crystals were filtered off. Yield 1.85 g (26%) (XXXVI) NMR (see Table I).
Workup
- customThe solution was evaporated
- temperatureThe received oil was refluxed in 40 ml of 2N NaOH
- filtrationThe crystals were filtered off
Sources & evidence
- ORD record
- ord-945ddb6c76414631b2f297afe3a1010f
- Source dataset
- uspto-grants-1987_02
- Patent number
- US04644001
Reaction notes
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