Sodium borohydride → 1,4-Bis(6-chloropyridin-3-yl)butane-1,4-diol
Reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][CH2:10][C:11]([C:13]2[CH:14]=[N:15][C:16]([Cl:19])=[CH:17][CH:18]=2)=[O:12])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C>[Cl:19][C:16]1[N:15]=[CH:14][C:13]([CH:11]([OH:12])[CH2:10][CH2:9][CH:8]([C:5]2[CH:6]=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[OH:20])=[CH:18][CH:17]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The product from Example 207A (2.90 g, 9.38 mmol) and sodium borohydride (0.745 g, 19.70 mmol) were combined in ethanol (94 mL) at 0° C. The mixture was warmed to room temperature and stirred for 6 hours. The solvent was evaporated and the residue was partitioned between ethyl acetate and 1M HCl. The organic layer was washed with water, brine, dried with sodium sulfate, filtered and evaporated to give the title compound (2.62 g, 89%).