Water → HCID 25193405, compound
Reaction equation
[NH2:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][C:7]([F:13])=[CH:6][C:3]=1[C:4]#[N:5].[OH2:14]>ClCCl>[NH2:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][C:7]([F:13])=[CH:6][C:3]=1[C:4]([NH2:5])=[O:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of EXAMPLE 45B (13.9 g) in polyphosphoric acid (400 g) was stirred at 115° C. for 3 hours. After cooling, water and dichloromethane were added and the mixture stirred at ambient temperature for 10 minutes. The solid material was collected by filtration and recrystallized from methanol.
Workup
- temperatureAfter cooling
- filtrationThe solid material was collected by filtration
- customrecrystallized from methanol
Sources & evidence
- ORD record
- ord-396383b33c9840019b4f0ab85cb71e72
- Source dataset
- uspto-grants-2014_04
- Patent number
- US08697736B2
Reaction notes
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