Sulfuryl chloride → HCID 12581868, compound
Reaction equation
[CH:1]1[S:2][CH:3]=[C:4]2[C:10]=1[C:9](=[O:11])[NH:8][C:7]1[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=1[O:5]2.S(Cl)([Cl:19])(=O)=O>C(Cl)Cl>[Cl:19][C:3]1[S:2][CH:1]=[C:10]2[C:9](=[O:11])[NH:8][C:7]3[CH:12]=[CH:13][CH:14]=[CH:15][C:6]=3[O:5][C:4]=12Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
An 8.0 g. portion of thieno[3,4-b][1,5]benzoxazepin-10(9H)-one is suspended in 364 ml. of methylene chloride. A 3.27 ml. portion of sulfuryl chloride is added dropwise and the mixture is stirred overnight. The solid is collected and washed with methylene chloride, giving 3-chloro-thieno[3,4-b][1,5]benzoxazepin-10(9H)-one.
Workup
- customThe solid is collected
- washwashed with methylene chloride
Sources & evidence
- ORD record
- ord-01e344525ecb49d88c449d4a323f91d4
- Source dataset
- uspto-grants-1979_06
- Patent number
- US04157444
Reaction notes
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