Iodine → 1260149-80-1

HRID 236983

Reaction equation

HRID 236983 reaction equation
[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][CH2:16]/[C:17](=[CH:18]\[CH:19]=[C:20]3\[CH2:21][C@@H:22]([OH:27])[CH2:23][CH2:24][C:25]\3=[CH2:26])/[C@@H:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:8])[CH3:7].II>CCCCCC>[CH3:1][C@@H:2]([C@@H:9]1[C@@:13]2([CH3:28])[CH2:14][CH2:15][CH2:16]/[C:17](=[CH:18]\[CH:19]=[C:20]3/[CH2:21][C@@H:22]([OH:27])[CH2:23][CH2:24][C:25]/3=[CH2:26])/[CH:12]2[CH2:11][CH2:10]1)[CH2:3][CH2:4][CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

4

Reactant 2

HCID 807IodineHCID 5280795Vitamin D3

Product 1

HCID 123030991260149-80-1Yield 61.3%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To a solution of Vitamin D3 (750 mgs) in hexane (20 ml) was added iodine (2 mgs). After stirring for 1 hr. at 20° the solution was washed with aqueous sodium thiosulphate, water and dried over sodium sulphate. After removal of the solvent, chromatography afforded trans-vitamin D3 (460mgs).

Workup

  1. washat 20° the solution was washed with aqueous sodium thiosulphate, water
  2. dry with materialdried over sodium sulphate
  3. customAfter removal of the solvent, chromatography

Sources & evidence

ORD record
ord-663b0618c75145368eab0ce7fa61ecd4
Source dataset
uspto-grants-1979_06
Patent number
US04159326

Linked notes

Loading…