Acetylpyrazine → (1R)-2-(methylamino)-1-pyrazin-2-ylethanol

HRID 23707

Reaction equation

[CH3:1][NH:2][CH2:3][C@H:4]([C:6]1[CH:11]=C[CH:9]=[CH:8][N:7]=1)[OH:5].C(C1C=NC=C[N:16]=1)(=O)C>>[CH3:1][NH:2][CH2:3][C@H:4]([C:6]1[CH:11]=[N:16][CH:9]=[CH:8][N:7]=1)[OH:5]

Participants

Reactant 2

HCID 30914Acetylpyrazine

HCID 10149007(R)-2-(methylamino)-1-pyridin-2-ylethanol

Product 1

HCID 10285809(1R)-2-(methylamino)-1-pyrazin-2-ylethanol

Procedure

As described for the preparation of (1R)-2-(methylamino)-1-pyridin-2-ylethanol, 2-acetylpyrazine is converted to the title compound, isolated as a light orange liquid that solidified on standing.

Sources & evidence

ORD record: ord-9fab06d9d2534561af800b10e0244e64
Source dataset: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06852731B2

Linked notes

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