Tert-Butanesulfinamide → (4-(Trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methanamine Hydrochloride

HRID 2370752

Reaction equation

[ClH:1].[F:2][C:3]([F:23])([F:22])[C:4]1[CH:9]=[CH:8][C:7]([C@@H:10]([C:12]2[C:17]([C:18]([F:21])([F:20])[F:19])=[CH:16][CH:15]=[CH:14][N:13]=2)[NH2:11])=[CH:6][CH:5]=1.CC(S(N)=O)(C)C>>[ClH:1].[F:22][C:3]([F:2])([F:23])[C:4]1[CH:5]=[CH:6][C:7]([CH:10]([C:12]2[C:17]([C:18]([F:21])([F:19])[F:20])=[CH:16][CH:15]=[CH:14][N:13]=2)[NH2:11])=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 3382465Tert-Butanesulfinamide

HCID 86687962(S)-(4-(Trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methanamine Hydrochloride

Product 1

HCID 89310363(4-(Trifluoromethyl)phenyl)(3-(trifluoromethyl)pyridin-2-yl)methanamine Hydrochloride

Procedure

Following the procedure detailed above for Intermediate 2, but replacing (S)-2-methylpropane-2-sulfinamide with racemic 2-methylpropane-2-sulfinamide in STEP 2 gave the title compound as a white solid.

Sources & evidence

ORD record: ord-84188d0a739249749c8875fb196a34b6
Source dataset: uspto-grants-2014_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08710043B2

Linked notes

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