Sodium Acetate → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)-1,2,4-triazolo[4,3-b]-1,2,4-triazine

HRID 237088

Reaction equation

HRID 237088 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9]([CH:11]=O)=O)[CH:6]=[CH:7][CH:8]=1.[NH2:15][C:16]1[N:20]([NH2:21])[CH:19]=[N:18][N:17]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[CH:11]=[N:21][N:20]3[CH:19]=[N:18][N:17]=[C:16]3[N:15]=2)[CH:4]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 5671443,4-Diamino-1,2,4-triazoleHCID 27832843-(Trifluoromethyl)phenylglyoxal

Product 1

HCID 125812597-(alpha,alpha,alpha-Trifluoro-m-tolyl)-1,2,4-triazolo[4,3-b]-1,2,4-triazine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 12.5 g. of m-trifluoromethylphenylglyoxal, 7.69 g. of 3,4-diamino-4H-1,2,4-triazole and 4.67 g. of sodium acetate in 120 ml. of 67% acetic acid is reacted as described in Example 4, giving the desired product as a yellow solid, m.p. 288°-290° C. (dec.).

Sources & evidence

ORD record
ord-f4851c6324344971a5eec2736d4ea614
Source dataset
uspto-grants-1979_06
Patent number
US04159375

Linked notes

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