Formaldehyde → 1-(2-Butoxyethoxy)ethanol
Reaction equation
C(O[CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11]O)C.C=[O:14].[C:15]1([CH3:21])C=CC=CC=1>O>[CH2:10]([O:9][CH2:8][CH2:7][O:6][CH:5]([OH:14])[CH3:4])[CH2:11][CH2:15][CH3:21]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 400 g triethylene glycol monoethyl ether (2.2 mol), 48 g paraformaldehyde (1.6 mol), 150 ml toluene and 10 g of an acid ion exchange resin was refluxed for 6 hours in a 1 liter flask equipped with a water separator and reflux condenser. Filtration of the product followed by distillation gave a quantitative yield of the desired product.
Workup
- temperaturewas refluxed for 6 hours in a 1 liter flask
- temperaturereflux condenser
- filtrationFiltration of the product
- distillationfollowed by distillation
Sources & evidence
- ORD record
- ord-dfa250a878854003b6059284c5deecfa
- Source dataset
- uspto-grants-1992_03
- Patent number
- US05093432
Reaction notes
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