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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2371699Generated: October 23, 2026

Methyl (R)-(1-hydroxy-3-methylbutan-2-YL)carbamate → (4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-one

https://huagongshe.com/en/reaction/2371699

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl (R)-(1-hydroxy-3-methylbutan-2-YL)carbamateHCID 15714133—
SolventTolueneHCID 1140—
Product(4R)-4-(Propan-2-yl)-1,3-oxazolidin-2-oneHCID 641505—

Reaction Conditions

Temperature150 °C

Reaction Steps

27.2 g (168.7 mmol) of the compound from Example V are dissolved in 400 ml of toluene and stirred under reflux in an oil bath at 150° C. while passing in nitrogen.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05095006
Source datasetuspto-grants-1992_03
ORD IDord-7518c1e32d2b4d4fadb76a3e57559c1e
Source noteuspto-grants-1992_03