Methyl Isocyanate → HCID 13420167, compound
Reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH:6]1[CH2:9][NH:8][CH2:7]1.[CH3:16][N:17]=[C:18]=[O:19]>C1C=CC=CC=1>[F:15][C:2]([F:1])([F:14])[C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[O:5][CH:6]1[CH2:9][N:8]([C:18]([NH:17][CH3:16])=[O:19])[CH2:7]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To 4.5 g (0.02 mole) of 3-[2-(trifluoromethyl)phenoxy]azetidine stirring in 50 ml of dry benzene, was added slowly 1.2 g (0.02 mole) of methyl isocyanate at room temperature. Stirring was continued for 30 minutes. A solid formed, and after filtration was recrystallized from benzene to yield 3.5 g (68%), mp 134°-136°.
Workup
- customA solid formed
- filtrationafter filtration
- customwas recrystallized from benzene
- customto yield 3.5 g (68%), mp 134°-136°
Sources & evidence
- ORD record
- ord-1a3a609d96214fbe9589953797d87e93
- Source dataset
- uspto-grants-1992_03
- Patent number
- US05095014
Reaction notes
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