Ammonia → 4-Amino-2-n-butyl-6-methylpyrimidine

Reaction equation

[CH2:1]([C:5]1[N:10]=[C:9](Cl)[CH:8]=[C:7]([CH3:12])[N:6]=1)[CH2:2][CH2:3][CH3:4].[NH3:13]>>[NH2:13][C:9]1[CH:8]=[C:7]([CH3:12])[N:6]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[N:10]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 176064082-Butyl-4-chloro-6-methylpyrimidine

Product 1

HCID 199022284-Amino-2-n-butyl-6-methylpyrimidine

Procedure

The title compound is prepared from 2-n-butyl-4-chloro-6-methylpyrimidine (from Example 26) upon treatment with alcoholic ammonia as described by Marshall and Walker (J. Chem. Soc., 1951, 1004).

Sources & evidence

ORD record: ord-30c327485cf44fbdb83c7366a4faef26
Source dataset: uspto-grants-1992_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05100897

Reaction notes

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