Ammonia → 7-Nitroquinazolin-4-amine

HRID 237317

Reaction equation

HRID 237317 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([N+:12]([O-:14])=[O:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH3:15]>CO>[N+:12]([C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH2:15])=[N:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1)([O-:14])=[O:13]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 8306804-Chloro-7-nitroquinazoline

Product 1

HCID 136977987-Nitroquinazolin-4-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.6 g of 4-chloro-7-nitroquinazoline in 50 ml 7N ammonia in methanol was stirred overnight at rt and concentrated to dryness. The solid was suspended in water, filtered, rinsed with water followed by ether and dried overnight in vacuum oven to provide 0.98 g of 7-nitroquinazolin-4-amine (Compound 98-2).

Workup

  1. concentrationconcentrated to dryness
  2. filtrationfiltered
  3. washrinsed with water
  4. customdried overnight in vacuum oven

Sources & evidence

ORD record
ord-9c94a77e0d38476da509652811c7b21c
Source dataset
uspto-grants-2014_02
Patent number
US08642582B2

Linked notes

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