Benzyl isocyanate → (4-{[Benzyl({[3,5-bis(trifluoromethyl)benzoyl]amino} sulfonyl)amino]methyl}cyclohexyl)methyl 3-methoxyphenylcarbamate

Participants

Reaction Steps

Following procedure to make (9), 3-methoxyphenyl isocyanate was substituted for benzyl isocyanate and diisopropylethylamine substituted for triethylamine to give the title compound after purification. 1H NMR (500 MHz, DMSO-d6): δ 9.50 (s, 1H), 8.45 (s, 2H), 8.10 (s, 1H), 7.38 (d, 2H), 7.24 (t, 2H), 7.14 (m, 3H), 6.96 (d, 1H), 6.52 (d, 1H), 4.35 (s, 2H), 3.75 (d, 2H), 3.68 (s, 3H), 3.30 (water), 2.89 (d, 2H), 2.48 (DMSO), 1.63 (m, 4H), 1.42 (m, 1H), 1.29 (m, 1H), 0.66 (m, 4H).

Provenance & Evidence