Carbon Dioxide → HCID 68544872, compound

Reaction equation

N[C:2]1[C:7](Cl)=[CH:6][N:5]=[C:4]2[O:9][CH2:10][O:11][C:3]=12.[CH2:12]1[O:20]C2C(=NC=CC=2)[O:13]1.C(=O)=O>>[CH2:10]1[O:11][C:3]2[C:4](=[N:5][CH:6]=[CH:7][C:2]=2[C:12]([OH:20])=[O:13])[O:9]1

Participants

Reactant 3

HCID 280Carbon Dioxide

HCID 125630792H-[1,3]Dioxolo[4,5-b]pyridine

HCID 685486516-chloro-2H-[1,3]dioxolo[4,5-b]pyridin-7-amine

Product 1

HCID 68544872HCID 68544872, compoundYield 80%

Procedure

Using an analogous procedure to that described in the second paragraph of the portion of Example 1 that is concerned with the preparation of the starting material 4-amino-5-chloro-2,3-methylenedioxypyridine, 2,3-methylenedioxypyridine was reacted with carbon dioxide gas to give 2,3-methylenedioxypyridine-4-carboxylic acid in 80% yield; NMR Spectrum: (DMSOd6) 6.24 (s, 2H), 7.13 (d, 1H); 7.63 (d, 1H).

Sources & evidence

ORD record: ord-47b18c9deddc43029225f8abeaafdb2f
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07462623B2

Reaction notes

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