3-Iodophthalic acid → 3-Iodophthalic anhydride

HRID 2377014

Reaction equation

HRID 2377014 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=O)[C:3]=1[C:11]([OH:13])=[O:12]>C(OC(=O)C)(=O)C>[I:1][C:2]1[C:3]2[C:11](=[O:12])[O:13][C:5](=[O:7])[C:4]=2[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 1

HCID 2382313-Iodophthalic acid

Product 1

HCID 2820713-Iodophthalic anhydrideYield 65.2%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 3-iodophthalic acid (0.9 g, 3.08 mmol) in acetic anhydride (5 mL) was heated to reflux under nitrogen overnight. After cooling, the solvent was removed in vacuo and the residue purified by trituration with ethanol to give 4-iodo-2-benzofuran-1,3-dione (0.55 g, 65%).

Workup

  1. temperatureto reflux under nitrogen overnight
  2. temperatureAfter cooling
  3. customthe solvent was removed in vacuo
  4. customthe residue purified by trituration with ethanol

Sources & evidence

ORD record
ord-06b41cd4add44d28838ce483980247c8
Source dataset
uspto-grants-2008_12
Patent number
US07468393B2

Linked notes

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