4-Methylmorpholine → 1h-Pyrrolo[2,3-c]pyridine-5-carboxamide,1-[(4-fluorophenyl)methyl]-n-hydroxy-n-methyl-3-[[(tetrahydro-2h-pyran-4-yl)oxy]methyl]-

Participants

Reaction Steps

The title compound was prepared as in example 116, step 3, using 1-(4-fluorobenzyl)-3-[(tetrahydro-2H-pyran-4-yloxy)methyl]-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid, 2-chloro-4,6-dimethoxy-1,3,5-triazine, N-methyl morpholine, and N-methyl hydroxylamine hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.38-1.48 (m, 2H) 1.84-1.91 (m, 2H) 3.28-3.37 (m, J=10.74, 10.74, 2.78 Hz, 5H) 3.60 (ddd, J=8.84, 4.80, 4.55 Hz, 1H) 3.80 (ddd, J=11.49, 4.29, 4.17 Hz, 2H) 4.69 (s, 2H) 5.54 (s, 2H) 7.16 (t, J=8.97 Hz, 2H) 7.36 (dd, J=8.72, 5.43 Hz, 2H) 7.86 (s, 1H) 8.03 (s, 1H) 8.89 (s, 1H)

Provenance & Evidence