Ethyl 2-formylbutanoate → 2-(4-tert-Butyl-phenoxymethyl)-6-ethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

HRID 237826

Reaction equation

HRID 237826 reaction equation
[C:1]([C:5]1[CH:18]=[CH:17][C:8]([O:9][CH2:10][C@H:11]2[O:15][C:14]([NH2:16])=[N:13][CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C([O:21][C:22](=O)[CH:23]([CH:26]=O)[CH2:24][CH3:25])C>C(Cl)(Cl)Cl>[C:1]([C:5]1[CH:18]=[CH:17][C:8]([O:9][CH2:10][CH:11]2[O:15][C:14]3=[N:16][C:22](=[O:21])[C:23]([CH2:24][CH3:25])=[CH:26][N:13]3[CH2:12]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 289299Ethyl 2-formylbutanoateHCID 67060987(S)-5-(4-tert-butyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine

Product 1

HCID 250736112-(4-tert-Butyl-phenoxymethyl)-6-ethyl-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared from (S)-5-(4-tert-butyl-phenoxymethyl)-4,5-dihydro-oxazol-2-ylamine and 2-formyl-butyric acid ethyl ester employing the procedure described in Step2 of Example 87. [α]D25 −31.20 (c 0.5, CHCl3).

Sources & evidence

ORD record
ord-2a1325e2405746c6bec9718275e8c03c
Source dataset
uspto-grants-2014_02
Patent number
US08642603B2

Linked notes

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