Ethyl chloroformate → Ethyl 5-(tetrahydro-2H-pyran-2-yloxy)-2-pentynoate

HRID 237847

Reaction equation

[CH2:1]([O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][O:7]1)[CH2:2][C:3]#[CH:4].Cl[C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH2:16]([O:15][C:13](=[O:14])[C:4]#[C:3][CH2:2][CH2:1][O:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][O:7]1)[CH3:17]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 1424402-(3-Butynyloxy)tetrahydro-2H-pyran

Product 1

HCID 365785Ethyl 5-(tetrahydro-2H-pyran-2-yloxy)-2-pentynoate

Procedure

The title compound was prepared from 2-but-3-ynyloxy-tetrahydro-pyran and ethyl chloroformate in accordance with the procedures of G. Cai et al., Tetrahedron, 2006, (5697-5708).

Sources & evidence

ORD record: ord-ddef041b63a14923a58fe31ec86684c1
Source dataset: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08642603B2

Linked notes

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