Acetic Anhydride → 6-Acetylaminomethyl-2-pyridinecarbonitrile
Reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.Cl.[NH2:9][CH2:10][C:11]1[N:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][CH:12]=1>N1C=CC=CC=1>[C:5]([NH:9][CH2:10][C:11]1[N:16]=[C:15]([C:17]#[N:18])[CH:14]=[CH:13][CH:12]=1)(=[O:7])[CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Acetic anhydride (1.29 ml) was added dropwise to a mixture of 6-aminomethyl-2-pyridinecarbonitrile hydrochloride (2.10 g) in pyridine (21 ml). The solution was stirred for four hours at ambient temperature and evaporated in vacuo. The residue was mixed with aqueous potassium carbonate and extracted with ethyl acetate. The extract was dried over magnesium sulfate and evaporated in vacuo to give 6-(acetylaminomethyl)-2-pyridinecarbonitrile (1.72 g).
Workup
- customevaporated in vacuo
- additionThe residue was mixed with aqueous potassium carbonate
- extractionextracted with ethyl acetate
- dry with materialThe extract was dried over magnesium sulfate
- customevaporated in vacuo
Sources & evidence
- ORD record
- ord-750d36444abc47ff9d0ab5ed66e21b92
- Source dataset
- uspto-grants-1994_11
- Patent number
- US05364871
Reaction notes
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