1-methyl-5-(2-phenylethenyl)-1H-pyrazole → 1-Methyl-5-(2-phenylethyl)-1H-pyrazole

HRID 238359

Reaction equation

HRID 238359 reaction equation
[CH3:1][N:2]1[C:6]([CH:7]=[CH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=[N:3]1>[C].[Pd].C(O)C>[CH3:1][N:2]1[C:6]([CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:5][CH:4]=[N:3]1

Participants

4

Reactant 1

HCID 714019871-methyl-5-(2-phenylethenyl)-1H-pyrazole

Product 1

HCID 866848621-Methyl-5-(2-phenylethyl)-1H-pyrazoleYield 102.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

10% Palladium carbon (30 mg) was added to an ethanol (3.0 mL) solution of 1-methyl-5-(2-phenylethenyl)-1H-pyrazole (300 mg), and the obtained solution was then stirred under a hydrogen atmosphere at a room temperature for 14 hours. Thereafter, the reaction solution was filtrated with Celite, and the filtrate was then concentrated under a reduced pressure, so as to obtain the title compound (310 mg) in the form of a colorless oily substance.

Workup

  1. filtrationThereafter, the reaction solution was filtrated with Celite
  2. concentrationthe filtrate was then concentrated under a reduced pressure

Sources & evidence

ORD record
ord-50ee3e6cf35c4f86b305a317eca7ecc6
Source dataset
uspto-grants-2014_02
Patent number
US08642626B2

Linked notes

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