Piperidine, 1-methyl,4-methylene- → N-[3-(1-Methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide

HRID 238432

Reaction equation

HRID 238432 reaction equation
CN1CCC(=C)CC1.BrC1C=C(NC(=O)C)C=C(C(F)(F)F)C=1.[N:24]1([CH2:30][CH2:31][CH2:32][C:33]2[CH:34]=[C:35]([NH:43][C:44](=[O:46])[CH3:45])[CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=2)[CH2:29]CC[CH2:26][CH2:25]1>>[CH3:29][N:24]1[CH2:25][CH2:26][CH:32]([C:33]2[CH:34]=[C:35]([NH:43][C:44](=[O:46])[CH3:45])[CH:36]=[C:37]([C:39]([F:40])([F:41])[F:42])[CH:38]=2)[CH2:31][CH2:30]1

Participants

4

Reactant 3

HCID 139537Piperidine, 1-methyl,4-methylene-HCID 21959349N-[3-bromo-5-(trifluoromethyl)phenyl]acetamideHCID 21959446N-[3-(3-Piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide

Product 1

HCID 21959571N-[3-(1-Methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide

Procedure

N-[3-(1-Methylpiperidin-4-yl)-5-trifluoromethyl-phenyl]-acetamide was prepared from 1-methyl-4-methylene-piperidine and N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide similar to that described in the preparation of N-[3-(3-piperidin-1-yl-propyl)-5-trifluoromethyl-phenyl]-acetamide.

Sources & evidence

ORD record
ord-6ca2077412b84c1eb269faedc73ba527
Source dataset
uspto-grants-2014_02
Patent number
US08642624B2

Linked notes

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