5-Bromosalicylic acid → 5-Bromo-N-(5-methyl-4-phenylthiazol-2-yl)-2-hydroxybenzamide

HRID 2384468

Reaction equation

HRID 2384468 reaction equation
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([CH3:24])=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][C:15]([CH3:24])=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 69725-Bromosalicylic acidHCID 961292-Amino-4-phenyl-5-methylthiazole

Product 1

HCID 178601415-Bromo-N-(5-methyl-4-phenylthiazol-2-yl)-2-hydroxybenzamide

Procedure

Using 5-bromosalicylic acid and 2-amino-5-methyl-4-phenylthiazole as the raw materials, the same operation as the example 16 gave the title compound. (2-Amino-5-methyl-4-phenylthiazole: refer to Yakugaku Zasshi, 1961, 81, 1456.)

Sources & evidence

ORD record
ord-b7942165c08442c1b7b007b93019773e
Source dataset
uspto-grants-2012_09
Patent number
US08263657B2

Linked notes

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