4-(3,5-Dimethyl-4H-1,2,4-triazol-4-yl)piperidine → HCID 67243211, compound

HRID 2384728

Reaction equation

HRID 2384728 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCCC)=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[CH3:33][C:34]1[N:38]([CH:39]2[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)[C:37]([CH3:45])=[N:36][N:35]=1>>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:42]5[CH2:41][CH2:40][CH:39]([N:38]6[C:34]([CH3:33])=[N:35][N:36]=[C:37]6[CH3:45])[CH2:44][CH2:43]5)=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:30])([F:31])[F:32])[CH:3]=1

Participants

3

Reactant 2

HCID 447213534-(3,5-Dimethyl-4H-1,2,4-triazol-4-yl)piperidineHCID 672409345-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one

Product 1

HCID 67243211HCID 67243211, compound

Procedure

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidin-1-yl]-thiazol-4-one was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one and 4-(3,5-Dimethyl-[1,2,4]triazol-4-yl)piperidine following General Procedure B.

Sources & evidence

ORD record
ord-d891467d880d4a9fa2f03bc2ead84023
Source dataset
uspto-grants-2012_09
Patent number
US08263781B2

Linked notes

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