HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminopentan-1-ol → N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminopentan-1-ol | HCID 75634 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | methyl 3-(N-vinylformamido)propionate | HCID 10964771 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(5-hydroxypentyl)-3-(N-vinylformamido)propionamide | HCID 19690346 | — |
Reaction Steps
The apparatus of Example 2 was charged with 15.7 grams (0.1 mol) of methyl 3-(N-vinylformamido)propionate, 10.3 grams (0.1 mol) of 5-amino-1-pentanol and 0.12 gram of 25% sodium methoxide in methanol solution. The mixture was stirred at 90° C. for 3 hours after which the methanol coproduct was removed by distillation at reduced pressure. NMR analysis of the remaining amber liquid indicated about 69% conversion to the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728878 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-575fdaab9b024e09a2ac34fb099e5fd0 |
| Source note | uspto-grants-1998_03 |