Thionyl Chloride → 2-Fluoropyridine-3-carbonyl chloride
Reaction equation
[F:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O=S(Cl)[Cl:13]>>[F:1][C:2]1[C:7]([C:8]([Cl:13])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1Participants
3
Procedure
2-Fluoropyridine-3-carboxylic acid (7 g, Step C) was suspended in SOCl2 (100 mL). After heating under reflux for 2 h, the mixture became homogeneous. Excess SOCl2 was removed in vacuo to afford a brown solid as desired product.
Workup
- temperatureAfter heating
- temperatureunder reflux for 2 h
- customExcess SOCl2 was removed in vacuo
Sources & evidence
- ORD record
- ord-9a43b48ccf53428fb07ec0624f068c33
- Source dataset
- uspto-grants-2014_02
- Patent number
- US08642624B2
Reaction notes
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