[6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester → [4-(4-Methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

Participants

Reaction Steps

To a solution of [6-chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (110 mg, 0.26 mmol) in methanol (3 mL) was added 10% palladium on carbon (10 mg). The resulting mixture was vigorously stirred at room temperature overnight under a hydrogen atmosphere (balloon) and then filtered. The filtrate was concentrated in vacuo to give [4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (68 mg, 67%) as a colorless oil which was directly used in the next step without further purification.

Provenance & Evidence